In the evolving landscape of Microbiome Science, Bifidobacterium longum BB536 stands as one of the most thoroughly researched and multifunctional probiotic strains in the world. As a Human-Residential Bifidobacterium (HRB), its compatibility with the human gut is unparalleled, making it the "Gold Standard" for OEM manufacturers and global healthcare brands.
Global procurement for BB536 has surged by over 25% annually, driven by a paradigm shift in consumer behavior. No longer satisfied with generic "probiotics," modern consumers demand strain-specific efficacy. From infant formula in Asia to cognitive health supplements in North America, BB536 is the cornerstone of high-performance functional nutrition.
Our technical route utilizes high-density fermentation technology, ensuring maximum CFU (Colony Forming Units) recovery. By controlling nitrogen levels and pH in real-time, we maintain the genetic stability of the BB536 strain across batches.
To overcome the oxygen sensitivity of B. longum, we employ a proprietary lyophilization (freeze-drying) process. This creates a "micro-shield" around the bacteria, allowing for room-temperature stability for up to 24 months.
We provide multiple delivery formats, including enteric-coated capsules, sachets, and specialized oil drops for pediatric use, ensuring the probiotics survive gastric acid to reach the lower intestine.
Benefiting from the solid foundation provided by its parent company, Xi'an Tianben Bioengineering Co., Ltd., Botanical Cube Inc. focuses on researching, developing, producing and selling healthy natural ingredients. With more than two decades of industry experience, it has become a leader in the field, specializing in providing high-quality plant extracts and customized solutions to global customers.
Our operations are supported by three companies - Xi'an Tianben Bioengineering Co., Ltd., Botanical Cube Inc. and Shaanxi Tianben Kangyuan Biotechnology Co., Ltd. - which together operate 3 production bases covering more than 100 acres and process more than 3,000 tons of plant raw materials each year. Exporting to 60% of the world's countries, serving more than 500 customers from all walks of life.
Years Experience
Annual Raw Material
Plant Extracts
Export Countries
Established in 2012 in Sanyuan City, Xi'an, our primary facility represents the pinnacle of industrial biotechnology. We have invested heavily in technology, training, and quality control to strengthen our capabilities.
Powder collection, crushing and sieving, mixing and drying processes are all performed in a Class 100,000 cleanroom environment. Our operators strictly follow hygiene protocols and wear sterile gowns, masks and gloves to maintain product purity and safety.
Our BB536 production meets the highest international standards, including FDA GRAS, EFSA compliance, and HALAL/KOSHER certifications, facilitating seamless entry into global markets.
We provide localized formulation support, adapting BB536 dosages and blends to meet regional regulatory requirements in the EU, USA, and SE Asia.
Every shipment is accompanied by a comprehensive Certificate of Analysis (COA) and stability data, ensuring 100% traceability from raw material to finished powder.
BB536 is a Human-Residential Bifidobacterium (HRB). Unlike strains sourced from animals or environment, HRB strains have superior colonization capabilities in the human gut and a long history of safe use in over 30 countries.
We utilize a multi-step stabilization process, including low-temperature spray drying and moisture-barrier packaging, ensuring the bacteria remain viable throughout their shelf life without the need for constant refrigeration.
Yes, we provide full-service OEM solutions, from strain blending (e.g., BB536 + Prebiotics) to finished capsule production, bottling, and labeling in our 100,000-class clean room.
Standard MOQ starts at 1kg for high-potency powders, though we can accommodate smaller pilot batches for R&D and clinical trial purposes.
Botanical
