Wholesale Bitter Orange Extract Nobiletin Powder Factories, Factory

CAS No.: 478-01-3

Specification: 60% Nobiletin

Appearance: Yellow to orange fine powder

Test Method: HPLC

Solubility: Insoluble in water, soluble in ethanol

Applications: Antioxidant Anti-inflammatory Anti-aging Repair

Package: 1–25kg or customized

Sample: 10–50g Sample For free

Storage: Cool dry place away from direct sunlight

Certificates: ISO22000, Kosher, Halal, Organic(EU), USDA, FSSC22000, FDA, SGS, cGMP

Shelf life: 2 years, Available in bulk, Private Label/OEM&ODM

Product Description

Bitter Orange Extract Nobiletin Powder - A Potent Anti-Aging Citrus Bioflavonoid

Our bitter orange extract nobiletin powder (also known as sour orange extract or sour orange flavonoid complex) is standardized with highly purified nobiletin, a polymethoxylated flavonoid extracted from the peel of bitter orange (Citrus aurantium). Nobiletin has been clinically demonstrated to possess dual benefits for metabolic health, cognitive function, anti-inflammatory, and antioxidant properties.

Global demand for bitter orange extracts rich in nobiletin is surging, particularly in functional foods, nootropics, and metabolic health formulations. As a high-quality citrus flavonoid, it offers advantages over standard synephrine bitter orange extracts, including a safer, less irritating, and broader clinical application. Our proprietary extraction technology ensures a nobiletin content of ≥60% as determined by HPLC, preserving complementary bioactive compounds such as tangeretin and citrullin, resulting in improved bioavailability and potency compared to isolated nobiletin. In addition, we support OEM customization services, including customized particle size and formulations optimized for beverage/softgel solubility.

Why choose our bitter orange extract Nobiletin powder?

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High Purity and Potency

Guaranteed nobiletin content ≥60% (HPLC verified), a full spectrum of hesperidin components, and the preservation of synergistic flavonoids such as tangeretin (≥5%) and bitter orange (≥3%) for enhanced bioavailability.

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Proprietary Extraction Technology

Low-temperature ethanol extraction preserves heat-sensitive bioactive components, and specialized emulsification technology increases absorption by 2-3 times compared to standard powders.

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OEM-focused Advantages

Customized particle size (60-100 mesh) allows for optimal blending into capsules, tablets, or granules. Pre-formulated anti-aging complexes (such as nobiletin + NMN) accelerate your product development.

COA (Certificate of Analysis)

Item Specification Result Test Method
Assay (Nobiletin) ≥ 60.0% 60.58% HPLC
Appearance Yellow to orange fine powder Conforms Visual
Odor & Taste Characteristic Conforms Organoleptic
Mesh Size 95% pass 80 mesh Conforms Screening
Loss on Drying ≤ 5.0% 3.42% USP <731>
Heavy Metals ≤ 10 ppm < 5 ppm ICP-MS
Total Plate Count ≤ 1,000 CFU/g 120 CFU/g USP <2021>

Applications of Bitter Orange Extract Nobiletin

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Dietary Supplements

Used in capsule or tablet form to promote fat metabolism and help maintain a healthy weight.

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Cognitive Health

Added to formulations designed to improve memory, learning, and neuroprotection.

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Skincare & Cosmetics

Due to its antioxidant properties, it is used in anti-aging or skin-brightening formulations.

Recommended Dosage

Dietary Supplements: Typically 50-200 mg daily, depending on the formulation and intended effect.
Functional Beverages: 0.05-0.2% by weight of the final product to provide antioxidant support.
Cosmetic Applications: Add 0.1-0.5% to creams or serums to enhance antioxidant effects.

*Note: Dosage should always comply with local regulations and safety assessments.

Frequently Asked Questions

1. Is nobiletin from bitter orange safe?

Generally, it is safe when taken at recommended doses. It is extracted from natural citrus peels and is a widely recognized bioflavonoid.

2. Does nobiletin aid in weight loss?

Research suggests that when combined with diet and exercise, it can promote healthy lipid metabolism and fat management.

3. Is it water-soluble?

Nobiletin is slightly soluble in water but more soluble in ethanol or oil. Our specialized extraction can be optimized for specific solubility needs.

4. What is the shelf life of this powder?

When stored in a cool, dry place away from direct sunlight, the shelf life is typically 24 months.

5. Can I use this for private label products?

Yes, we offer flexible OEM solutions and custom blending services to help brands accelerate their product development.

6. How is the purity verified?

Every batch is tested via High-Performance Liquid Chromatography (HPLC) to ensure the nobiletin content meets or exceeds 60%.

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