Explore our highly certified bio-compounds curated for worldwide commercial formulations
Chrysin, chemically classified as 5,7-dihydroxyflavone (C15H10O4), is a naturally occurring flavone subclass polyphenol extracted from plants such as Passiflora coerulea (blue passionflower), Oroxylum indicum (Indian trumpet flower), as well as in therapeutic honeybee propolis. Regarded as one of the most powerful natural anti-aromatase inhibitors, Chrysin has transitioned from a niche dietary supplement to a vital ingredient in systemic wellness, hormonal optimization, and high-performance skincare applications.
In human biochemistry, Chrysin targets the aromatase enzyme (CYP19), which is responsible for converting testosterone into estrogen. By binding to this enzyme's active site, Chrysin assists in balancing hormone profiles, making it a staple in sports nutrition formulations and testosterone-booster products globally. Furthermore, emerging clinical studies demonstrate its ability to inhibit NF-κB inflammatory pathways, suppress oxidative stress within cellular matrices, and downregulate key markers of tumor progression. Its high-potential skin barrier enhancement capability has additionally driven its inclusion in innovative cosmetic formulations aimed at addressing hyperpigmentation and fine lines.
For B2B procurement managers, sourcing high-purity Chrysin is key to formulation stability and legal compliance. Our commercial batch specifications guarantee:
Understanding the challenges of bulk supply chains, quality stability, and regulatory landscapes.
The main challenge of raw Chrysin is low oral bioavailability due to rapid glucuronidation. As an OEM manufacturer, we offer co-formulation solutions incorporating natural bio-enhancers, such as Piperine Extract, or lipid-based microencapsulation technologies to enhance absorption rates up to 5-fold.
For exports to the EU, USA, and Japan, control of pesticide residues (compliant with European Pharmacopoeia 2.8.13) and residual solvents is non-negotiable. Our manufacturing process uses eco-friendly solvents, ensuring clean-label end products.
Whether you require standard 80-mesh powder for capsule filling, ultrafine micronized powder for rapid dissolution, or direct-compression (DC) grade granules for tableting, our engineering team modifies physical properties without degrading chemical integrity.
A look at the advanced purification processes that deliver high purity Chrysin.
Our natural Chrysin begins with the identification of high-yield botanicals like Oroxylum indicum seeds. Through optimized ethanol reflux extraction or supercritical CO2 fluid extraction, we harvest the raw flavonoid fractions while preserving structural integrity and avoiding heavy thermal degradation.
The extracted crude paste is subjected to adsorption resin column chromatography. By adjusting mobile phase polarities, we isolate Chrysin from related flavones like Baicalein and Wogonin. This phase guarantees an intermediate purity of >85%.
Using food-grade ethanol and water-based solvent mixtures, Chrysin undergoes repeated recrystallization. This process purifies the compound to ≥99% and yields the signature pale yellow crystalline format, ensuring minimal residual impurities.
Inside our Class 100,000 cleanroom, the crystalline structure is pulverized using air-jet mills to achieve specific particle size dimensions. The batch is then double-bagged in food-grade polyethylene inside fiber drums, with oxygen and moisture barriers inserted to maximize storage shelf life.
| Feature | Natural Extract (Oroxylum indicum) | Synthetic Chrysin (Chemical Synthesis) |
|---|---|---|
| Purity Potential | 98% - 98.5% HPLC | ≥99.0% HPLC (Ultra-Pure) |
| Heavy Metals / Residues | Extremely low, natural profile (organic trace elements) | Requires monitoring of heavy metal catalysts |
| Consumer Perception | High ("Clean Label", natural origin preference) | Moderate (Cost-effective for bulk therapeutic formulas) |
| Supply Stability | Subject to seasonal agricultural yields | Highly stable, high capacity year-round production |
| Pricing Structure | Premium pricing based on solvent and plant costs | Economical for large-scale sports nutrition applications |
Built on decades of biotechnical excellence to supply raw materials worldwide.
Benefiting from the solid foundation provided by its parent company, Xi'an Tianben Bioengineering Co., Ltd., Botanical Cube Inc. focuses on researching, developing, producing, and selling healthy natural ingredients. With more than two decades of industry experience, it has become a leader in the field, specializing in providing high-quality plant extracts and customized solutions to global customers.
Our premium raw material solutions meet the needs of industries including herbal medicine, health foods, dietary supplements, food and beverages, daily chemicals, and cosmetics.
Our operations are supported by three integrated enterprises - Xi'an Tianben Bioengineering Co., Ltd., Botanical Cube Inc., and Shaanxi Tianben Kangyuan Biotechnology Co., Ltd. - which together operate 3 production bases covering more than 100 acres and process more than 3,000 tons of plant raw materials each year.
The product range includes more than 200 plant extracts, and we also provide a variety of certified organic products to meet the global demand for environmentally friendly and healthy solutions. Exporting to 60% of the world's countries, serving more than 200 countries and regions and more than 500 customers from all walks of life.
Our first factory was established in 2012 in Sanyuan City, Xi'an, four years after our company was founded. At that time, our production experience was still in its early stages, and we faced many challenges as we worked to refine our processes. However, we remained committed to continuous improvement, investing heavily in technology, training, and quality control to strengthen our capabilities. These early efforts laid a strong foundation for our future growth, shaping the high standards of excellence that we uphold today.
Powder collection, crushing and sieving, mixing, and drying processes are all performed in a Class 100,000 cleanroom environment. Our operators strictly follow hygiene protocols and wear sterile gowns, masks, and gloves to maintain product purity and safety, ensuring that we provide our customers with high quality standards and reliable ingredients.
Navigating regulatory standards and local compliance requirements.
We supply complete documentation including DMF (Drug Master Files), Technical Dossiers (TDS), MSDS, and batch-specific COAs. All shipments are certified under ISO 9001, ISO 22000, Kosher, Halal, and GMP requirements.
Our raw Chrysin batches undergo independent validation by third-party laboratories (such as SGS or Eurofins) to verify chemical purity and confirm the absence of heavy metals, solvent residues, and microbiological contaminants.
We work with established carriers and offer customs assistance to ensure reliable delivery to North America, Europe, and the Asia-Pacific region. Our storage warehouses help maintain consistent product availability.
Scientific and logistical insights for B2B procurement managers and R&D scientists.
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