Explore our high-performance ingredient portfolio certified for global cosmetic, nutraceutical, and clinical formulations.
Ceramides constitute approximately 50% of the lipid matrix in the human stratum corneum. In modern clinical dermatology and cosmetic formulation science, these intercellular lipids are crucial for retaining skin moisture, optimizing transepidermal water loss (TEWL), and protecting against exogenous pathogens. However, the commercial extraction and chemical engineering of ceramides represent a high-barrier-to-entry market.
For global brands, sourcing reliable raw materials involves understanding the nuances between plant-derived phytoceramides, bio-fermented human-identical ceramides (such as Ceramide NP, Ceramide AP, and Ceramide EOP), and synthetic variations. Partnering with a specialized OEM ceramides supplier ensures consistent stereochemical purity, optimal solubility, and superior clinical performance.
As a global leader in natural active ingredients, Botanical Cube Inc., in alliance with its parent corporation Xi'an Tianben Bioengineering Co., Ltd., delivers pharmaceutical-grade, bio-fermented ceramides engineered to easily integrate into advanced skincare systems. We focus on enhancing the bioavailability of ceramides through nanotechnology, microencapsulation, and liposomal delivery systems.
Combining legacy experience with state-of-the-art bioengineering plants across China.
Benefiting from the solid foundation provided by its parent company, Xi'an Tianben Bioengineering Co., Ltd., Botanical Cube Inc. focuses on researching, developing, producing and selling healthy natural ingredients. With more than two decades of industry experience, it has become a leader in the field, specializing in providing high-quality plant extracts and customized solutions to global customers.
Our business model bridges raw botanical extraction and advanced biotech synthesis. Our services meet the needs of industries including herbal medicine, health foods, dietary supplements, food and beverages, daily chemicals and cosmetics.
Our operations are supported by three dynamic corporate entities - Xi'an Tianben Bioengineering Co., Ltd., Botanical Cube Inc. and Shaanxi Tianben Kangyuan Biotechnology Co., Ltd. - which together operate 3 production bases covering more than 100 acres and process more than 3,000 tons of plant raw materials each year. Our product range includes more than 200 plant extracts, and we also provide a variety of certified organic products to meet the global demand for environmentally friendly and healthy solutions.
Years of Biotech R&D Experience
Advanced Production Bases
Acres of Industrial Facility
Exported to Global Markets
Operational safety, sterile environments, and rigorous compliance at the heart of Shaanxi's biotech corridor.
Our first factory was established in 2012 in Sanyuan City, Xi'an, four years after our company was founded. At that time, our production experience was still in its early stages, and we faced many challenges as we worked to refine our processes. However, we remained committed to continuous improvement, investing heavily in technology, training, and quality control to strengthen our capabilities. These early efforts laid a strong foundation for our future growth, shaping the high standards of excellence that we uphold today.
Over the past decade, we have updated Sanyuan Factory with highly automated fermentation and extraction lines. Today, the facility operates in complete compliance with cGMP guidelines, validating each batch of ceramides for biological purity, moisture content, heavy metal limits, and microbiology parameters.
Powder collection, crushing and sieving, mixing and drying processes are all performed in a Class 100,000 cleanroom environment. Our operators strictly follow hygiene protocols and wear sterile gowns, masks and gloves to maintain product purity and safety, thus ensuring that we provide our customers with high quality standards and reliable ingredients.
This controlled atmosphere regulates pressure differentials, airflow, and particle concentration, preventing cross-contamination during the delicate final packaging stages of our active ingredients.
How Botanical Cube Inc. maximizes productivity, guarantees cost-efficiency, and delivers high-performance logistics.
Operating across 3 dedicated production bases encompassing 100+ acres allows us to process 3,000+ tons of materials annually. This scale significantly minimizes costs relative to smaller operations, enabling competitive B2B pricing on high-purity ceramides.
Based in Xi'an, Shaanxi Province, our facilities link directly to transcontinental rail lines and major ocean ports. This proximity reduces transit times and shipping rates for our clients in over 200 countries and regions worldwide.
By leveraging yeast strains like Wickerhamomyces ciferrii, our factories run high-yield bio-fermentation cycles. This process yields bio-identical Ceramides (NP, AP, EOP) with superior chemical stability and lower environmental impact compared to historical chemical methods.
Ceramides are highly versatile and widely utilized across different global markets. The optimal physical form—whether oil-soluble powder, water-dispersible liquid, or micro-liposome—depends directly on the target product formulation.
Clinical Barrier Creams & Lotions: Typically formulated in a 3:1:1 ratio combining Ceramide NP, Cholesterol, and Free Fatty Acids to mimic and repair the natural lipid matrix of the skin. Key for eczema-prone or highly sensitive skin types.
Hair Repair Treatments: Targeted for damaged cuticles, Ceramides bind scales together, protecting the cortex from heat damage and chemical styling. Crucial for premium professional salons and hair repair brands.
Nutraceuticals & Beauty Supplements: Phytoceramides sourced from rice or wheat can be taken orally to help moisturize the skin from within. They are digested, transported, and deposited into the stratum corneum, helping reduce dryness throughout the body.
Ideal dosage for standard barrier creams: 0.05% to 1.0%. Highly compatible with Niacinamide, Glycerin, Hyaluronic Acid, and botanical extracts like Oat Oil.
Pure ceramide powder requires heating up to 80°C - 85°C within the oil phase of formulations. Alternatively, use water-soluble or pre-dispersed liquid systems for cold-process manufacturing.
Completely compliant with global cosmetic raw material regulations, including China IECIC, EU Cosmetics Regulation (EC 1223/2009), and USA FDA Voluntary Cosmetic Registration Program.
Evaluating raw material purity, stereospecificity, and supply chain predictability for modern brands.
Natural human skin contains specific optical isomers of ceramides. Synthetic molecules often include unnatural D/L racemic mixes that are less effective. Our yeast-fermented Ceramides offer 100% human-identical configurations, ensuring maximum biological recognition and efficacy.
Modern consumers actively seek vegan and carbon-neutral formulations. Our bio-fermentation processes eliminate the need for harsh chemical reagents or animal-derived source materials, helping brands align with clean beauty standards.
Given current global logistics challenges, brands require partners with substantial production capabilities and warehousing options. Botanical Cube Inc.'s 3 facilities process over 3,000 tons of natural ingredients annually, protecting client brands from supply disruptions.
Answering technical questions commonly asked by cosmetic formulators, quality assurance managers, and global procurement directors.
High-quality raw extracts and organic solutions designed to support your product line.
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