OEM PDRN (Polydeoxyribonucleotide) powder Supplier, Factories

Specification: 98% purity 

Appearance: White to off-white fine powder

Test Method: HPLC, UV Spectrophotometry

Solubility: Soluble in water and physiological saline

Applications: Skincare,healing Aesthetic medicine

Package: 1–25kg or customized

Sample: 10–50g sample for free

Storage: Cool, dry place away from direct sunlight

Certificates: ISO22000, Kosher, Halal, Organic (EU), USDA, FSSC22000, FDA, SGS, cGMP

Shelf life: 2 years; available in bulk; Private Label/OEM & ODM

Product Description

PDRN Powder: The Next Generation of Skin Regeneration and Cellular Renewal

PDRN powder is a powerhouse raw material, globally recognized under its scientific name, Polydeoxyribonucleotide. It is also frequently referred to in the cosmetics industry as PN (Polynucleotide) or even Salmon DNA (when derived from that source) and PhytoPDRN (for plant-based alternatives).

PDRN is a naturally occurring biopolymer, a DNA fragment, typically purified from salmon or trout DNA, though advanced biotech methods now yield high-purity, plant-derived versions. Its molecular structure makes it a potent active ingredient.

PDRN's mechanism of action is its unique ability to interact directly with the skin's cellular infrastructure. It functions by activating the A2A adenosine receptor, which acts like a biological switch, triggering a cascade of beneficial effects. In essence, Polydeoxyribonucleotide (PDRN) doesn't just mask the signs of aging; it works at a deep cellular level to renew and reinforce the skin's fundamental structure, delivering true regenerative results.

  • Stimulating Cellular Repair: PDRN directly supports the skin's natural healing and regenerative processes, making it exceptional for post-treatment recovery and barrier strengthening.
  • Boosting Collagen Synthesis: It actively stimulates fibroblasts—the cells responsible for producing collagen and elastin—leading to improved skin firmness, elasticity, and a visible reduction in fine lines and wrinkles.
  • Anti-Inflammatory & Soothing: By modulating the body's inflammatory response, PDRN helps calm irritated, sensitive, or compromised skin, reducing redness and promoting a smoother texture.

The global market for PDRN is experiencing exponential growth, particularly within the aesthetic and cosmeceutical sectors. Initially dominating professional injectable treatments in South Korea (K-Beauty) for its "skin booster" effects, PDRN is now rapidly trending in topical skincare worldwide. Consumers are actively seeking this regenerative ingredient as a clinically backed alternative to overused components like Hyaluronic Acid, driven by viral content and dermatologist recommendations.

PDRN (Polydeoxyribonucleotide) powder 2
Why our PDRN (Polydeoxyribonucleotide) powder?
1. High Purity & Bioactivity

Our "salmon DNA extract" consistently achieves a purity level exceeding 98%, verified by HPLC analysis. We rigorously control the molecular weight range between 50 kDa and 1,500 kDa to ensure effective pathway activation.

2. 20 Years of Biomaterial Expertise

Source Integrity: Partnered with sustainable fisheries certified for purity, ensuring traceability and eliminating viral risks.
Advanced Processing: Low-temperature enzymatic hydrolysis protects DNA strands from denaturation.

3. OEM Synergy

Formulation Intelligence: Guidance on compatible excipients and optimal buffer systems (pH 6.5-7.5) for long-term stability.
Customization: Tailored particle sizes and custom active ingredient blends.

COA Specification Table
Item Specification Result Test Method
Product Name PDRN (Polydeoxyribonucleotide) Powder Complies /
CAS No. 83661-07-0 83661-07-0 /
Appearance White to off-white fine powder Conforms Visual
Odor Odorless Conforms Organoleptic
Identification Positive (UV absorption at 260 nm) Positive UV Spectrophotometry
Assay (Purity, Dry basis) ≥98.0% 99.12% HPLC
Molecular Weight 350–500 kDa 410 kDa GPC
pH (1% aqueous solution) 6.0 – 8.0 7.1 pH Meter
Solubility Soluble in water and saline Conforms Visual
Moisture (Loss on Drying) ≤5.0% 2.3% USP <731>
Ash ≤2.0% 0.6% USP <281>
Heavy Metals (as Pb) ≤10 ppm <5 ppm ICP-MS
Arsenic (As) ≤2 ppm <1 ppm ICP-MS
Cadmium (Cd) ≤1 ppm <0.5 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm <0.05 ppm ICP-MS
Residual Solvents ≤0.5% <0.1% GC
Endotoxin Level ≤0.5 EU/mg 0.21 EU/mg LAL Assay
Nucleic Acid Integrity ≥90% intact 93.8% Agarose Gel Electrophoresis
Microbial Limit: Total Plate Count ≤1000 CFU/g <100 CFU/g USP <61>
Yeast & Mold ≤100 CFU/g <10 CFU/g USP <61>
E. coli Negative Negative USP <62>
Salmonella Negative Negative USP <62>
Staphylococcus aureus Negative Negative USP <62>
Particle Size 100% through 80 mesh Conforms Mesh Screening
Bulk Density 0.35–0.55 g/mL 0.46 g/mL Tapping Density Test
Shelf Life 24 months Conforms /
Storage Cool, dry place, away from direct sunlight Conforms /
Applications of PDRN (Polydeoxyribonucleotide) Powder
  • Widely used in anti-aging skincare formulations to promote cell regeneration, collagen synthesis, and DNA repair, resulting in smoother, firmer, and more elastic skin.
  • Commonly applied in cosmetic serums, ampoules, masks, and skin boosters to accelerate skin recovery after laser, peeling, or microneedling treatments.
  • Incorporated in anti-wrinkle and repair creams to reduce fine lines and improve overall skin texture.
  • Utilized in mesotherapy and aesthetic injectables to enhance tissue regeneration, boost hydration, and brighten dull skin.
  • Applied in after-sun or post-treatment soothing products to reduce inflammation and redness.
  • Used in hair care formulas to nourish scalp cells, improve microcirculation, and stimulate hair follicle activity for healthier hair growth.
Recommended Dosage
  • Cosmetic formulations: 0.1% – 2% depending on product type and formulation base.
  • Topical repair gels or serums: 0.5% – 1.5%.
  • Skin booster or mesotherapy solutions: 1% – 2%, under professional supervision.
  • Hair care products: 0.1% – 0.5%.
PDRN Powder Supplier & OEM Partner

Ready to lead the regenerative beauty trend? When you choose us, you get more than just a raw material; you get a manufacturing partner offering the market's highest-purity PDRN powder for maximized efficacy. We hold necessary certifications, including cGMP and ISO standards, ensuring seamless compliance for your global product launch. Let's discuss how our specialist OEM solutions—particularly our expertise in bioavailability to guarantee effective topical delivery—can make your next bulk order of Polydeoxyribonucleotide a market success story.

Frequently Asked Questions (FAQs)
Is PDRN safe for daily skincare use?
Yes, PDRN is derived from purified DNA fragments (usually from salmon) and is biocompatible with human skin, making it safe for daily use when formulated correctly.
What is the difference between PDRN and PN (Polynucleotide)?
PDRN is a specific type of polynucleotide with a defined molecular weight range (350–500 kDa) optimized for skin regeneration, while PN is a broader category including various DNA fragment types.
Can PDRN be combined with other active ingredients like hyaluronic acid or peptides?
Absolutely. PDRN works synergistically with hyaluronic acid for deep hydration and with peptides for enhanced tissue regeneration and elasticity.
Why is PDRN popular in Korean skincare?
Because it's proven to support skin regeneration at the cellular level, many Korean aesthetic and cosmeceutical brands use it in high-end rejuvenating products.
What is the recommended molecular weight for optimal PDRN efficacy?
The molecular weight range should be controlled between 50 kDa and 1,500 kDa (typically optimized around 350-500 kDa). This size range is scientifically designed to properly activate the Adenosine A2A Receptor pathway.
What is the recommended dosage range for different topical applications?
Recommended dosages vary by application: 0.1% to 2% for general cosmetic formulations, 0.5% to 1.5% for topical repair gels or serums, 1% to 2% for professional skin boosters, and 0.1% to 0.5% for hair care formulations.

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