PDRN powder is a powerhouse raw material, globally recognized under its scientific name, Polydeoxyribonucleotide. It is also frequently referred to in the cosmetics industry as PN (Polynucleotide) or even Salmon DNA (when derived from that source) and PhytoPDRN (for plant-based alternatives).
PDRN is a naturally occurring biopolymer, a DNA fragment, typically purified from salmon or trout DNA, though advanced biotech methods now yield high-purity, plant-derived versions. Its molecular structure makes it a potent active ingredient.
PDRN's mechanism of action is its unique ability to interact directly with the skin's cellular infrastructure. It functions by activating the A2A adenosine receptor, which acts like a biological switch, triggering a cascade of beneficial effects. In essence, Polydeoxyribonucleotide (PDRN) doesn't just mask the signs of aging; it works at a deep cellular level to renew and reinforce the skin's fundamental structure, delivering true regenerative results.
The global market for PDRN is experiencing exponential growth, particularly within the aesthetic and cosmeceutical sectors. Initially dominating professional injectable treatments in South Korea (K-Beauty) for its "skin booster" effects, PDRN is now rapidly trending in topical skincare worldwide. Consumers are actively seeking this regenerative ingredient as a clinically backed alternative to overused components like Hyaluronic Acid, driven by viral content and dermatologist recommendations.
Our "salmon DNA extract" consistently achieves a purity level exceeding 98%, verified by HPLC analysis. We rigorously control the molecular weight range between 50 kDa and 1,500 kDa to ensure effective pathway activation.
Source Integrity: Partnered with sustainable fisheries certified for purity, ensuring traceability and eliminating viral risks.
Advanced Processing: Low-temperature enzymatic hydrolysis protects DNA strands from denaturation.
Formulation Intelligence: Guidance on compatible excipients and optimal buffer systems (pH 6.5-7.5) for long-term stability.
Customization: Tailored particle sizes and custom active ingredient blends.
| Item | Specification | Result | Test Method |
|---|---|---|---|
| Product Name | PDRN (Polydeoxyribonucleotide) Powder | Complies | / |
| CAS No. | 83661-07-0 | 83661-07-0 | / |
| Appearance | White to off-white fine powder | Conforms | Visual |
| Odor | Odorless | Conforms | Organoleptic |
| Identification | Positive (UV absorption at 260 nm) | Positive | UV Spectrophotometry |
| Assay (Purity, Dry basis) | ≥98.0% | 99.12% | HPLC |
| Molecular Weight | 350–500 kDa | 410 kDa | GPC |
| pH (1% aqueous solution) | 6.0 – 8.0 | 7.1 | pH Meter |
| Solubility | Soluble in water and saline | Conforms | Visual |
| Moisture (Loss on Drying) | ≤5.0% | 2.3% | USP <731> |
| Ash | ≤2.0% | 0.6% | USP <281> |
| Heavy Metals (as Pb) | ≤10 ppm | <5 ppm | ICP-MS |
| Arsenic (As) | ≤2 ppm | <1 ppm | ICP-MS |
| Cadmium (Cd) | ≤1 ppm | <0.5 ppm | ICP-MS |
| Mercury (Hg) | ≤0.1 ppm | <0.05 ppm | ICP-MS |
| Residual Solvents | ≤0.5% | <0.1% | GC |
| Endotoxin Level | ≤0.5 EU/mg | 0.21 EU/mg | LAL Assay |
| Nucleic Acid Integrity | ≥90% intact | 93.8% | Agarose Gel Electrophoresis |
| Microbial Limit: Total Plate Count | ≤1000 CFU/g | <100 CFU/g | USP <61> |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g | USP <61> |
| E. coli | Negative | Negative | USP <62> |
| Salmonella | Negative | Negative | USP <62> |
| Staphylococcus aureus | Negative | Negative | USP <62> |
| Particle Size | 100% through 80 mesh | Conforms | Mesh Screening |
| Bulk Density | 0.35–0.55 g/mL | 0.46 g/mL | Tapping Density Test |
| Shelf Life | 24 months | Conforms | / |
| Storage | Cool, dry place, away from direct sunlight | Conforms | / |
Ready to lead the regenerative beauty trend? When you choose us, you get more than just a raw material; you get a manufacturing partner offering the market's highest-purity PDRN powder for maximized efficacy. We hold necessary certifications, including cGMP and ISO standards, ensuring seamless compliance for your global product launch. Let's discuss how our specialist OEM solutions—particularly our expertise in bioavailability to guarantee effective topical delivery—can make your next bulk order of Polydeoxyribonucleotide a market success story.